высокие уровни кетоновых тел помогают кишечнику поддерживать большой пул взрослых стволовых клеток

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

https://www.cell.com/cell/fulltext/S0092-8674(19)30848-7?fbclid=IwAR3Yz-cuxmrYQcg0zDfM49jfbKkk3ukC88E1FCYeHWijuEXnqsKVmC91-6A

Неожиданный эффект кето диеты

Биологи Массачусетского технологического института обнаружили неожиданный эффект кетогенной или богатой жирами диеты: они доказали, что высокие уровни кетоновых тел (молекул, образующихся при расщеплении жира) помогают кишечнику поддерживать большой пул взрослых стволовых клеток, которые имеют решающее значение для поддержания здоровой слизистой оболочки кишечника. Исследователи также обнаружили, что кишечные стволовые клетки производят необычно высокий уровень кетоновых тел даже при отсутствии диеты с высоким содержанием жиров. Эти кетоновые тела активируют хорошо известный сигнальный путь, называемый Notch, который, как ранее было доказано, помогает регулировать дифференцировку стволовых клеток . «Кетоновые тела являются одним из первых примеров того, как метаболит определяет судьбу стволовых клеток в кишечнике», — говорит Омер Йилмаз ( Omer Yilmaz ), профессор биологии Айзена и Чанга по развитию карьеры и член Института интеграционных исследований рака им. Коха при Массачусетском технологическом институте. «Кетоновые тела, которые играют важную роль в поддержании энергии во время стресса при питании, используя путь Notch для улучшения функции стволовых клеток. Изменения уровней кетоновых тел при различных состояниях питания или диетах позволяют стволовым клеткам адаптироваться к разной физиологии.» В исследовании на мышах было обнаружено, что кетогенная диета дала кишечным стволовым клеткам регенеративный импульс, который позволил им лучше восстанавливаться после повреждения слизистой оболочки кишечника, по сравнению со стволовыми клетками мышей на обычном питании.


Далее в источнике: https://proautism.info/keto-diet/


Источник: https://proautism.info/keto-diet/

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